Current management strategies involve the use of pharmacotherapy, when indicated, in the event of deep venous thrombosis or pulmonary embolism. You must do the 25-minute 5-Factor workout five days a week. The amount of weight that you can lose, however, depends on many things, including your size, gender, and activity level. Do you recommend genetic testing for any of my family members? They were hot, red, and huge. Do I need to take medication to prevent additional blood clots? Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). If you are overweight or obese, consider the benefits of losing weight. Get useful, helpful and relevant health + wellness information. About 1 out of 10,000 people will develop a DVT or PE each year. Kaushansky K, et al., eds. That's important because high blood pressure can damage blood vessels, increasing blood clot risk. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The mutation in itself is not a reason to avoid donating blood, but you should not give blood if you are using an anticoagulant (blood thinner). The prevalence of factor V Leiden varies by ethnicity. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. The factor V Leiden mutation itself doesnt cause any symptoms. There is also a 50% chance that your child will inherit your normal Factor V gene. If you cant walk around, flex your ankles and point your toes up and down. 0000003553 00000 n
A prothrombin gene mutation can raise your risk of getting a pulmonary embolism or deep venous thrombosis. Factors that increase this risk include: Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). Can the results of the test affect my ability to obtain health insurance? 0000001440 00000 n
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Anticoagulant Food-Drug Interactions. Your F5 gene controls the production of a protein called factor V, which helps your blood clot when needed (such as after an injury). This site complies with the HONcode standard for trustworthy health information: verify here. This site complies with the HONcode standard for trustworthy health information: verify here. Avoidance of alcohol-containing beverages during long flights. If you are already taking an anticoagulant, make sure you keep regular appointments with your provider. What will a positive or negative result tell me? Start With This 7-Day Meal Plan, 10 Effortless Ways to Finally Cut Down on Salt. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. 0000002579 00000 n
Mango and St. Johns wort are also clinically relevant inhibitors of VKAs. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. %%EOF
But some people inherit mutated versions of this gene and develop a condition called factor V Leiden thrombophilia. People with this condition have a factor V Leiden mutation, meaning theres a change in their coagulation factor V (F5) gene. We do not endorse non-Cleveland Clinic products or services. The risk increases with age: Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater . Both men and women can have factor V Leiden. As a result, too much blood clotting can happen. In 2010 I was pregnant with my son. How long will it take to get results back? If youre having a deep vein thrombosis or pulmonary embolism, your provider will typically treat you with anticoagulants (blood thinners) and occasionally with thrombolytic (clot-busting) medicines. These conditions can be life-threatening and require immediate medical treatment. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. Mayo Clinic, Rochester, Minn. June 17, 2018. This content does not have an English version. If you want to increase the amount you're eating, your doctor can help you make the adjustment slowly, with appropriate adjustments to your medication. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. The following supplements are theoretically capable of inhibiting VKAs, but their clinical effect is insignificant: Studies have shown that there is a 58% higher likelihood of achieving PT-INR values in the optimal therapeutic range of 2.0 to 3.0 if patients on VKA medication avoid herbal supplements or take them three or fewer times a week. Talk with your doctor about the risks and benefits of taking these medications. During long car rides, stop every few hours and take a short walk. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. of signs you need emergency medical attention or call 911. She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming. How experienced is the lab at performing this test? Vitamin K is found in the following foods: Liver meat Broccoli Brussels sprouts Cabbage Cheese Collard greens Kale Lentils Flaxseed Lettuce Spinach Soybean oil Turnip greens Camomile Green tea. The clot remains in place while other enzymes repair the damaged blood vessel. Factor V Leiden is the name of one such blood clotting disorder. For children with one affected gene, the chance of getting a blood clot increases 10 times. A cough that produces bloody or blood-streaked sputum. Advertising on our site helps support our mission. Because its an inherited condition, you cant prevent the prothrombin gene mutation. A. You won't go hungry on The 5-Factor Diet. Healthy fats: Eat healthy fats each day such as olive oil, nuts, seeds and avocado. Your doctor may suspect factor V Leiden if you've had one or more episodes of abnormal blood clotting or if you have a strong family history of abnormal blood clots. Most notably, you will need to be aware of your vitamin K consumption. The 5-Factor Diet is a bundled diet and exercise plan that may help you lose weight and become more active. When taken with anticoagulants, binge-drinking alcohol can increase INR values. If you have factor V Leiden and have developed blood clots, anticoagulant medications can lessen your risk of developing additional blood clots and help you avoid potentially serious complications. 0000006483 00000 n
Accessed June 4, 2018. 3. Advertising revenue supports our not-for-profit mission. Some people do not have the normal Factor V protein. However, some people with this disorder develop DVT or PE. 2. Factor V Leiden. If you have other chronic conditions such as diabetes, work with your health team to manage your health. You may inherit an abnormal Factor II gene from one or both parents. Policy. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. Research is mixed concerning the weight loss advantage of eating smaller meals more often, but this may have other health benefits. It is not a disease. It increases the chances that your blood will form abnormal blood clots that can be dangerous. Factor V Leiden. If you have the heterozygous type, there is a 50% chance that your child will inherit a Factor V Leiden gene from you. Cleveland Clinic is a non-profit academic medical center. Accessed June 4, 2018. Foods to limit when you're following a heart-healthy diet include: 1. In addition, this mutation only increases the risk of vein clots (deep vein thrombosis or pulmonary embolism). Make a donation. If you have the prothrombin gene mutation but never had a deep vein thrombosis or pulmonary embolism before, you will not need a blood thinner during or after pregnancy. We inherit one gene from our mother and one from our father. You have 1 Factor V Leiden gene from one parent and 1 normal Factor V gene from your other parent. Factor V Leiden is the most common inherited condition causing increased blood clotting. Here are a few to help you start the conversation: Factor V is a coagulation factor, or protein, in your blood. I WAS DIAGNOSED IN MARCH OF THIS YEAR AFTER HAVING MY 2ND PULMONARY EMBOLISM. small children have a risk of 1 in 100,000 per year, those in their twenties have a risk of 1 in 10,000 per year, by age 40, this risk is 1 in 1,000 per year. The liver is responsible for breaking down alcohol and some medications, and this may cause a slower than normal metabolism of the anticoagulant, increasing the drug concentration in the blood, and hence the risk of bleeding. Youll prepare and eat five, 5-ingredient meals a day (each takes 5 minutes to prepare) and do 25-minute workouts (consisting of five, 5-minute segments) five times a week. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. The NATIONAL BLOOD CLOT ALLIANCE works to advance #bloodclot awareness, prevention, diagnosis, & successful treatments to #stoptheclot. If youve been diagnosed with DVT or a PE, youll have frequent follow-up appointments so your provider can check treatment progress. About 1 of every 250 Black people in America has the prothrombin gene mutation. Deep vein thrombosis and pulmonary embolism. NBCA provides the information and materials on this site for general information purposes only. Yes, you can pass on the gene for this disorder to your children. Where's the Health Benefit? Its also important to talk to your provider: Seek emergency medical care if you develop symptoms of deep vein thrombosis or a pulmonary embolism. Low-salt, low-fat: The plan is already geared toward low-fat and low-salt foods and may be adjusted further if needed. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: 1. 0000002967 00000 n
In a healthy individual who is bleeding, platelets and clotting factors or specific proteins form a clot to stop the bleeding. THE DOCTORS COULD NOT FIGURE OUT WHERE MY BLOOD CLOTS WERE COMING FROM SINCE I DID NOT HAVE ANY DVT'S. One of these factors is Factor V (FV) Leiden (rs6025), which is a missense variant caused by a single nucleotide polymorphism (SNP) in the F5 gene. The factor V Leiden mutation itself doesnt have any specific treatment. If youre taking warfarin, youll need routine blood testing (prothrombin time test) to check how well your medication is working. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. DVT or a PE during or shortly following pregnancy. The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. As a result, factor V works in overdrive, making your blood more likely to clot when it shouldnt. 0000007474 00000 n
Mayo Clinic, Rochester, Minn. June 17, 2018. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. 0000002423 00000 n
But you should talk to your provider about what you can expect in your individual situation. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. (2019, May 20). Barbara Woodward Lips Patient Education Center. Factor V Leiden resists the effects of Activated Protein C, so it takes longer to turn off Factor V Leiden. But its important that these individuals discuss with their doctors what they should be aware of and what they can do to minimize the risk of DVT or PE. Having Factor V Leiden does not appear to increase the chances of developing a heart attack or stroke. Middeldorp S, Coppens M. Hereditary Thrombophilia. 1-ranked heart program in the United States. xref
This is why Factor V Leiden is sometimes called Activated Protein C Resistance and why people with this mutation clot more than those without it. Symptoms of deep vein thrombosis in your arm or leg include: Symptoms of a pulmonary embolism (located in your lung) include: It is a genetic mutation in your Factor II gene that makes it create too much prothrombin (coagulation factor II), and you end up with a higher risk of developing blood clots than someone with a normal prothrombin gene. Some people only need treatment for three months, but others will need blood thinner treatment indefinitely. If you have kidney disease, there may be too much protein in this diet for you. 0000001362 00000 n
News-Medical. Whole grains: Choose whole grains like whole-grain bread, quinoa, farro and brown rice rather than refined grains, such as white bread, white rice, crackers and baked goods made with white flour. High-Protein Diets -- Do They Really Work? The Meat Effect: Protein, Carbs, and Your Diet. Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). Maybe youve already had to deal with a blood clot and wonder if youll face another.